Breakthroughroughrough Wajan Bincike

Kwanan nan, Jama Oncology (idan 33.012) ya buga sakamakon bincike na Jami'ar Shanghai Jio Jam'iyyar Fudiyya da Caifactulation na Cancis na Mataki na III Tumik methy bin da haɗarin haɗarin) ". Wannan binciken shi ne nazarin da yawa na farko a duniya don amfani da fasahar fasahar CTDNA da kuma saka idanu na maimaitawa, kuma yana samar da ingantaccen rayuwa mai lalacewa da ingancin rayuwa. Hakanan an gayyaci nazarin ta hanyar Jaridar da kuma editar, kuma an gayyaci matsayin babbar takarda a wannan batun, kuma farfesa Juan Ruan Ruia daga cikin Amurka ya gayyaci shi don duba shi. Hakanan an ruwaito binciken daga na na gaba na nazarin, babban kafofin watsa labarai na kafofin watsa labaru a Amurka.

Colorectal Cancer (CRC) cuta ce ta gama gari game da gastrointestestast na cikin gida. Hukumar Kula da Kasa da Kasa da Kasa kan Cinikin Cutar (iARC) ta nuna cewa sabbin lamuran na kasar Sin 555,000 a cikin asusun kasar Sin game da 1/3 na duniya, tare da ragi a matsayin na biyu na cututtukan daji a kasar Sin; Asusun mutuwa 286,000 na kusan 1/3 na duniya, a matsayin na biyar da ya fi na kowa dalilin mutuwar cutar kansa a China. Na biyar sanadin mutuwa a China. Abin lura ne cewa daga cikin marasa lafiya masu kamuwa da cutar, da TNM Stages i, II, III, IIV sune, 42.5%, kashi 30.7%, kashi 30%. More than 80% of the patients are in the middle and late stages, and 44% of them have simultaneous or heterochronic distant metastases to liver and lung, which seriously affect the survival period, endanger the health of our residents and cause heavy social and economic burden. Dangane da ƙididdigar Cancar cutar kansa ta ƙasa, matsakaita matsakaita shekara-shekara da ci gaban cutar kansa na cutar kansa a cikin shekara guda. Marasa lafiyar cutar kansa suna fama da cutar har ma a karkashin babbar matsin tattalin arziki [2].
Za'a iya cire ciyawar cutar cututtukan daji na cutarwa ta rauni, kuma a farkon lokacin tsinkaye na shekaru biyar, amma yawan dawowa na tsattsauran ra'ayi har yanzu kusan 30%. Amfanin na tsawon shekaru biyar na cutar kanshi a cikin yawan mutane na Colororal sune 90.1%, 72.6%, 53.8%, 53.8% na matakai 10.4.8% na matakai 10.4% don matakai na I, II, III da IV, bi da bii da iv, II, III da IV, bi da bii da iv, II, III da IV, II, III.
Laifalin ƙarancin ƙwayar cuta (MRD) babban dalili ne na sake haifar da maimaita ƙwayar tumo bayan radiccal magani. A cikin 'yan shekarun nan, fasahar ganowa na MRD don karfafa gwiwa da sauri da hadin kai tsaye sun tabbatar da hadarin dawowar mahaifa. Gwajin CTDNA yana da fa'idodi na zama marasa amfani, mai sauƙi, saurin, tare da babban wadatarwar injiniyoyi masu yawa da kuma shawo kan cutar cutar.
Jagororin NCCN don cutar kansa da cutar sankara ta kasar Sin, na iya samar da bayanan da ke tattare da matsalar rashin daidaituwa ga masu cutar cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cuta tare da yanayin ciwon daji na ii. Duk da haka, yawancin nazarin da ke da hankali sun mayar da hankali kan cutar CTDNA dangane da fasahar Siffering ta hanyar talla (NGS), wacce ke da ƙarancin ci gaba da ƙarancin marasa lafiya a tsakanin marasa lafiyar cutar kansa.
Game da batun tsayawa kan cutar kansa na III, Ngs-tushen CTDNA QTLAMIC har zuwa $ 10,000 don ziyarar guda kuma tana buƙatar lokacin jira na tsawon makonni biyu. Tare da gwajin methybane a cikin wannan binciken, mulkin mallaka, na mulkin mallaka na iya samun saka idanu na CTDNA mai tsauri a goma na farashin kuma sami rahoto a cikin kwana biyu.
Dangane da sabbin maganganu na cutar kansa 560,000 a kasar Sin a kowace shekara, Marasa kai na Clinical.
Ana iya ganin sakamakon bincike yana da mahimmanci kimiyya da amfani. Ta hanyar karatun asibiti mai cikakken mahimmanci, ya tabbatar da cewa ana iya amfani da fasahar ƙwayar cuta ta CTDNET PCR-tushen don ingantaccen magani tare da ci gaba da maganin cututtukan cututtukan daji don amfanin ƙarin cututtukan daji. Nazarin ya samo asali ne daga Kanada Methy Contray na da cutar kansa ta Kuny, wacce ta tabbatar da darajar aikace-aikacen asibiti da na asibiti.
Gastroenterology (IF33.88), Babban Journnationalasashen Kasa a fagen Jami'ar Fudan, wanda ya tabbatar da kyakkyawan aikin na kadaiqiriya da farkon bayyanar da shi Cutar cutar kansa, kuma da farko ta bincika shi kuma bincika aikace-aikacen da zai iya yuwuwar a kan abubuwan da cutar kansa na coloral.

Don kara tabbatar da aikace-aikacen asibiti na CTDNA methyation cikin haɗarin haɗari, ƙwararrun mai ɗaukar hoto a cikin mako ɗaya kafin tiyata, da wata ɗaya bayan tiyata, da wata daya bayan tiyata, da wata daya bayan tiyata, da wata daya bayan tiyata, da wata daya bayan tiyata Don gwajin kwastom mai jini.
Da farko, an gano cewa gwajin CTDNA na iya hango haɗarin sake dawowa a cikin marasa lafiyar cutar kansa da wuri da wuri da farko. Masu ba da labari na Ctdna-tabbatacce suna da babban yiwuwar sake dawowar enodopyopy fiye da marasa lafiyar Ctdna-mara kyau ba (22.0%> 4.7%). Farkon gwajin CTDNA na farko har yanzu ana gwada haɗarin sake zama: wata daya bayan matsin lamba, marasa lafiya masu kyau na CTDNA sun kasance sau 17.5 sau goma da yawa don dawo da marasa lafiya; Har ila yau, kungiyar ta gano cewa hade CTDNA da CEA ta tabbatar da ingantaccen aiki a cikin CTDNA (AUC = 0.849), amma Bambancin ba shi da muhimmanci idan aka kwatanta da CTDNA (AUC = 0.839).
Matsalar asibiti hade tare da abubuwan hadarin a yanzu haka ne babban tushen haɗarin cutar kansa da cutar kansa kamar yadda-jiyya da kuma cin amana a cikin asibitin. Dangane da wannan, ƙungiyar marasa galihu da ƙananan cututtukan daji na III zuwa kimantawa daban-daban na bincike (T4 / N2) da ƙarancin haɗari (3/6 watanni). Binciken ya gano cewa marasa lafiya a cikin manyan ƙananan ƙwayoyin CTDNA-tabbatattun marasa lafiya suna da ƙananan juyawa idan sun sami watanni shida na maganin adjnantarwa; A cikin ƙananan ƙwayoyin cuta mai haɗari na marasa lafiya na CTDNA, babu bambanci tsakanin tsarin kula da Adjuchan da sakamakon haƙuri; Yayin da marasa lafiya marasa kyau CtDna suka sami ingantaccen hango fiye da marasa lafiya mai kyau da masu tasowa da kuma bayan sake dawowa - lokaci mai tsayi (rfs); Matsayi na I da ƙananan haɗari na Motsi-hadarin cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan Ctdna duk marasa lafiya ba su sake komawa cikin shekaru biyu ba; Sabili da haka, an sa ran CTDNA tare da sifofin asibiti tare da ƙara inganta haɗarin haɗarin da mafi munin juyayi da kyau.

Hoto 1
Ganawar sakamakon gwajin CTDNACIC na Dynamic ya nuna cewa hadarin sake dubawa ya kasance mai matukar muhimmanci a lokacin da ake ci gaba da cutar CTDNA watanni 20), da kuma bayar da yiwuwar da wuri Gano na sake dawowar cuta da kuma saiti na lokaci.

Hoto na 2

"Babban adadi na karatun magunguna a cikin cutar kansa na CTDNA ya nuna kyakkyawar gudanar da karar cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan jini, jagora da yanke hukunci da kuma dawowa farkon mai dubawa.

Amfanin zabar DNA MOWYYLAND AS ABAR MOD MEMER MEMER SANARSA GA MAI KYAUTA, kuma yana nisanta sakamako na musamman da aka samo asali ne daga al'ada.
Wannan binciken da sauran binciken da suka shafi na masu dangantaka da CTDNA-tushen cutar CTDNA shine mafi mahimmancin yanke hukunci na gaba, kuma "ƙasa da Colorational Colorical Md shine mafi mahimmanci mai haɗari ga cutar kansa na I-III.
Filin mrd yana saurin motsawa da yawan sababbin abubuwa, mai matukar hankali da takamaiman aminantattun abubuwa) da kuma gentomin. Muna tsammanin cewa mulkin mallaka muna ci gaba da shirya manyan asibitoci kuma na iya zama sabon mai nuna ma'amala da mahimmancin aiki. "
Nassoshi
[1] moh s, Ye, Han L, Wang H, Dai W, LIO W, Cai G. Daga S, Wang Z, Wang Z, Wang Z, Wang Z, Wan Lai Jama Oncol. 2023 APR 20.
[2] "Wurin cutar ciwon kan cutar kansa a cikin yawan Sinawa: Shin an canza shi a cikin 'yan shekarun nan? , Jaridar Sin na Easidemiology, Vol. 41, A'a 10, Oktoba 2020.
[3] Tarazona N, Gimeno-Baliente f, Gambardiella v, et al. An yi niyya na gaba da ke tattare da keɓaɓɓen-dena DNA DNA don bin diddigin yanayi mai ƙarfi a cikin cutar kansa. Ann Oncol. Nuwamba, 2019; 30 (11): 1804-1812.
[4] Taib J, André T, AUCLININ E. Gyara adjnust na rashin daidaituwa don cutar kansa mara kyau, sababbin ka'idoji. Ciwon daji kula da Rev. 2019; 75: 1-11.